SAP30, a novel autophagy regulatory gene in neuroblastoma

Neuroblastoma (NB), a devastating pediatric cancer originating from neural crest cells crucial for nervous system development, poses a significant therapeutic challenge.Despite chemotherapy being the primary treatment, approximately 70% of high-risk NB cases develop resistance.Autophagy is vital for neuronal development, balance, and differentiatio

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Influence of a lifestyle intervention in preschool children on physiological and psychological parameters (Ballabeina): study design of a cluster randomized controlled trial

Abstract Background Childhood obesity and physical inactivity are increasing dramatically worldwide.Children of low socioeconomic status and/or children of migrant background are especially at risk.In general, the overall effectiveness of school-based programs on health-related outcomes has been disappointing.A special gap exists for younger childr

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Geological Composition and Structure of the Filling Zone and Its Water-Resisting Property Evaluation on the Top of Ordovician Limestone

With the gradual increase in mining depth of coal fields in North China, the threat posed by karstic Ordovician limestone water to the safe stoping of mines is becoming increasingly prominent.Investigating the water-resisting property of the filling zone on the top of the Ordovician limestone provides the key to safe mining under pressure.This pape

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